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Wheezing is a whistling sound that occurs during breathing, usually during expiration through narrowed airways. Inflammation of the airways, bronchospasm (tightening of the muscles around the bronchial tubes), and hypersensitivity (reactivity to triggers such as allergens, irritants, or infections) all play a role in the development of wheezing.

Cyanosis can also appear at any time later in life and often accompanies conditions in which lung function is compromised (resulting in an inability to fully oxygenate the blood) or conditions in which the hearts pumping function is compromised. The presence of abnormal forms of hemoglobin or other abnormalities of the blood cells can also sometimes cause cyanosis.

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